Agricultural and Biological Research

Acetobacter xylinum: Biochemical synthesis production and regulation of cellulose with c-di-GMP-binding protein

Haseena Muhammad* and Najla Ali Alburae

In consideration to BC, Acetobacter xylinum is considered as the known producer of cellulose and used in a lot of experiments. Variety of microorganisms and plants produce cellulose with several distinct mechanical and structural properties. However, Bacterial Cellulose (BC) has some unique properties of natural polymer and therefore considered as important candidate for biomedical applications, as it is free of impurities unlike to that of Plant Cellulose (PC), which use also cause environmental disaster. The initial discovery of c-di-GMP was in 1987, which controls variety of cellular processes and known as second messenger of bacteria. Cellular procedure like formation of the biofilm, virulence, motility, surface adapation and also bacterial pathogenicity are controlled by c-di-GMP. This review explains our current understanding about the biochemical synthesis of Acetobacter xylinum with morphological properties of cellulose. It highlights the pathway and activity of c-di-GMP with numerous biomedical applications and forthcoming plans.