Agricultural and Biological Research

Evaluation of Antiulcer activity of the poly-herbal combination extract

Dubey RS, Naidu MA, Tiwari A

Objective: Antiulcer activity of a Poly-Herbal Combination (PHCE) containing extracts of Gymnema sylvestre, Momordiaca charantia, Syzygium cumini, Trigonella foenum, Psidium guajava, Tinospora cardifolia, Boerhavia diffusa, Coriandrum sativum, Andrographis paniculata, mixture of Haritaki, Bibhitaki and Amalaki, mixture of black pepper and dry ginger and Withania somnifera was assessed in rats’ model.

Methods: The antiulcer activity of the poly-herbal combination extract (PHCE 300 and 500 mg/kg) was tested, as well as the therapeutic efficacy of PHCE. Findings: When the results of the evaluations were compared to the control group and standard medicine, PHCE (300 and 500 mg/Kg-1, p.o.) dose was found to be particularly protective against ethanol-induced, indomethacininduced and aspirin induced ulcer models.

Conclusion: Gymnema sylvestre, Momordiaca charantia, Syzygium cumini, Trigonella foenum, Psidium guajava, Tinospora cardifolia, Boerhavia diffusa, Coriandrum sativum, Andrographis paniculata, mixture of Haritaki, Bibhitaki and Amalaki, mixture of black pepper and dry ginger and Withania somnifera were discovered to have antiulcer action in PHCE. According to the findings, the PHCE can be employed in the treatment and management of stomach ulcer illness.